Did somebody say “design principles”? 🙂
In developing tissues, cells estimate their spatial position by sensing graded concentrations of diffusible signaling proteins called morphogens.
Morphogen-sensing pathways exhibit diverse molecular architectures, whose roles in controlling patterning dynamics and precision have been unclear.
the combination of double-negative regulatory logic and negative feedback through the PTCH receptor accelerates gradient formation and improves robustness to variation in the morphogen production rate compared with alternative designs.
During development and regeneration, tissue patterning unfolds with astonishing precision in space and time.
Diffusible signaling molecules known as morphogens provide a key patterning mechanism.
Morphogens are secreted by sender cells and form concentration gradients that are interpreted by cognate signaling pathways in receiver cells to generate distinct cell fate domains
Common Design 