Bone Marrow Transplantation Dynamics: When Progenitor Expansion Prevails
The transplantation of healthy hematopoietic stem cells (HSCs) contained in the bone marrow is a frontline treatment option for hematopoietic diseases. Detailed analysis of post-transplant HSC kinetics is crucial as the initial engraftment of HSCs influences prognosis. Dong et al. have explored the dynamic change in HSC cell fate upon bone marrow transplantation through the utilization of single-cell transcriptomic analysis.
A bone marrow transplant is a procedure that infuses healthy blood-forming stem cells into your body to replace your damaged or diseased bone marrow. A bone marrow transplant is also called a stem cell transplant.
You might need a bone marrow transplant if your bone marrow stops working and does not produce enough healthy blood cells.
Bone marrow transplants may use cells from your own body (autologous transplant) or from a donor (allogeneic transplant).
Common Design 