Mitochondria as intracellular signaling platforms in health and disease
Mitochondria, long viewed solely in the context of bioenergetics, are increasingly emerging as critical hubs for intracellular signaling.
mitochondria possess their own genome and carry unique lipid components that endow these organelles with specialized properties to help orchestrate multiple signaling cascades.
Mitochondrial signaling modulates diverse pathways ranging from metabolism to redox homeostasis to cell fate determination.
mitochondria serve as intracellular signaling platforms with a particular emphasis on lipid-mediated signaling, innate immune activation, and retrograde signaling.
these signaling properties might potentially be exploited to develop new therapeutic strategies for a range of age-related conditions.
Blending in and standing out, mitochondria are uniquely positioned to function as signaling hubs. Though expressed in hundreds of copies per cell, their unique composition and genome make them a complicated mix of the familiar and the distinct.
key questions remain unanswered
More research is needed… we look with much anticipation to reading future papers on new discoveries
Common Design 