The cell-wide web coordinates cellular processes by directing site-specific Ca²⁺ flux across cytoplasmic nanocourses

our observations point to the incredible signalling potential that may be afforded by modulating quantum Ca²⁺ flux on the nanoscale, in support of network activities within cells with the capacity to permit stimulus-dependent orchestration of the full panoply of diverse cellular processes. Perhaps more importantly, the cellular intranet conferred by the SR and its associated network activities are not hardwired, reconfiguring to deliver different outputs during phenotypic modulation on the path, for example, to cell proliferation. This in itself suggests that cytoplasmic nanocourses may be common to but vary in nature between different cell types. Supporting this, NE invaginations are a feature of many cell types while other junctional complexes of the S/ER vary by cell type and even between different smooth muscles.