The Functional 3D Organization of Unicellular Genomes

the co-localization of genes targeted by a transcription factor (TF) within a transcription factory

both Proteasome lid subcomplex genes and protein refolding genes jointly spatially co-localize at a shared location.

There are well established functional mechanisms that are known to interact in cis via genomic proximity, such as genes along an operon, promotors and their associated coding sequence, nucleosome modifications and proximal chromatin accessibility, etc.