Gastrulation

“It is not birth, marriage, or death, but gastrulation, which is truly the most important time in your life.”
            Lewis Wolpert (1986) 

 

I don’t agree with the above statement philosophically, but it shows that gastrulation is a fundamental biological process.

How is it regulated?   This is a fundamental topic that reveals purposefully designed control layers.   

It’s not the unknown, but what we know, that increasingly reveals engineered biological systems.   

Let’s look into this in details: gastrulation regulation.

During gastrulation, cell movements result in a massive reorganization of the embryo from a simple spherical ball of cells, the blastula, into a multi-layered organism. During gastrulation, many of the cells at or near the surface of the embryo move to a new, more interior location.

TET-mediated DNA demethylation controls gastrulation by regulating Lefty–Nodal signalling (2016)

Mammalian genomes undergo epigenetic modifications, including cytosine methylation by DNA methyltransferases (DNMTs).

These findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation and demethylation crucial to regulation of key signalling pathways in early body plan formation.