“It is not birth, marriage, or death, but gastrulation, which is truly the most important time in your life.”
Lewis Wolpert (1986)
I don’t agree with the above statement philosophically, but it shows that gastrulation is a fundamental biological process.
How is it regulated? This is a fundamental topic that reveals purposefully designed control layers.
It’s not the unknown, but what we know, that increasingly reveals engineered biological systems.
Let’s look into this in details: gastrulation regulation.
During gastrulation, cell movements result in a massive reorganization of the embryo from a simple spherical ball of cells, the blastula, into a multi-layered organism. During gastrulation, many of the cells at or near the surface of the embryo move to a new, more interior location.
TET-mediated DNA demethylation controls gastrulation by regulating Lefty–Nodal signalling (2016)
Mammalian genomes undergo epigenetic modifications, including cytosine methylation by DNA methyltransferases (DNMTs).
These findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation and demethylation crucial to regulation of key signalling pathways in early body plan formation.
