Nervous System Regionalization Entails Axial Allocation before Neural Differentiation
Neural induction in vertebrates generates a CNS that extends the rostral-caudal length of the body. The prevailing view is that neural cells are initially induced with anterior (forebrain) identity; caudalizing signals then convert a proportion to posterior fates (spinal cord).
Contrary to the established model, […] cells commit to a regional identity before acquiring neural identity.
This “primary regionalization” allocates cells to anterior or posterior regions of the nervous system, explaining how cranial and spinal neurons are generated at appropriate axial positions. These findings prompt a revision to models of neural induction
Development of the vertebrate nervous system begins at gastrulation and continues as the principal axis elongates, resulting in a nervous system extending along the anterior-posterior (AP) length of the body
Common Design 