EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development
Vascular endothelial growth factor (VEGF) is an angiogenic factor that play important roles in the nervous system, although it is still unclear which receptors transduce those signals in neurons.
Our results demonstrate the functional crosstalk of VEGFR2 and ephrinB2 in vivo to control dendritic arborization, spine morphogenesis and hippocampal circuitry development.
During development, the hippocampus undergoes typical stages of neuronal development involving proliferation, differentiation, synapse and circuit formation, and the maturation of synaptic connections. CA3 neurons are generated around E14.5 and CA1 neurons one day later at E15.5 (Grove, 1999). Neurogenesis of the dentate gyrus granule cell starts shortly before birth, peaks in the first postnatal week and continues until adulthood.
Our study describes a novel function for neuronal expressed VEGFR2 signaling in the development of the hippocampus.
Common Design 