Experience and changes in neuronal activity can alter CNS myelination, but the signalling pathways responsible remain poorly understood.
Together, these results indicate that the vasculature responds to changes in neuronal activity associated with experience by regulating endothelin levels, which in turn affect the myelinating capacity of oligodendrocytes. This pathway may be employed to couple the metabolic support function of myelin to activity-dependent demand and also represents a novel mechanism for adaptive myelination.
There is increasing evidence that experience regulates CNS myelination. For example, social interactions, sensory stimulation and several forms of learning have been shown to alter white matter and myelin structure in both humans and animal models
Common Design 