Rif1 choreographs DNA replication timing
Eukaryotic cells duplicate their genome in a pre‐determined order that appears to reflect a fundamental property of chromatin. Each chromosomal region replicates at a consistent, developmental‐ and tissue‐specific time during the S phase of the cell cycle, and regions that replicate at the same time form distinct patterns in three‐dimensional nuclear space. Although orderly progression of DNA replication is important for insuring stable genetic and epigenetic inheritance, the mechanisms underlying replication patterns have yet to be elucidated.
New work identifies Rif1 as a global determinant of the timing program that controls orderly progression of mammalian DNA replication to ensure stable genetic and epigenetic inheritance.
Common Design 