ZYG-1 promotes limited centriole amplification in the C. elegans seam lineage
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ZYG-1 promotes limited centriole amplification in the C. elegans seam lineage
Benita Wolf, Fernando R. Balestra, Antoine Spahr, Pierre Gönczy
DOI: 10.1016/j.ydbio.2018.01.001
The centrosome is the major microtubule-organizing center (MTOC) of animal cells, and as such plays fundamental roles in organizing the microtubule cytoskeletal network, including the mitotic spindle
Genome stability relies notably on the integrity of centrosomes and on the mitotic spindle they organize.
ZYG-1 promotes limited centriole amplification solely during the symmetric division in the C. elegans seam lineage.
extra centrosomes form strictly in some cells of a stereotyped stem cell lineage in C. elegans, raising the possibility that similar restricted consequences may operate in other systems and help explain the interplay between centrosome number aberrations and proliferation control.
Common Design 