=======
Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity
Elisa Vitiello, Philippe Moreau, Vanessa Nunes, Amel Mettouchi, Helder Maiato, Jorge G. Ferreira, Irène Wang & Martial Balland
Nature Communications volume 10, Article number: 52 (2019)
centriole duplication needs to be tightly regulated.
The mechanism driving centriole separation is poorly understood and little is known on how this is linked to centriole duplication.
actin-generated forces regulate centriole separation.
precise acto-myosin force arrangements control direction, distance and time of centriole separation.
acto-myosin forces might act in fundamental mechanisms of aneuploidy prevention.
Here we propose a “centriole force sensing” mechanism where acto-myosin forces modulate centriole separation and centrosomal recruitment of PLK4, to ultimately limit centriole duplication at only once per cell cycle.
this mechanism acts as a way for the cell to prevent aberrant duplication and limit possible aneuploidy onset.
Common Design 