Separation and Loss of Centrioles From Primordidal Germ Cells To Mature Oocytes In The Mouse
Mammalian oocytes lack centrioles, but how or at what stage mature eggs lose their centrioles during oogenesis is unknown.
In most mammals, haploid female gametes produced during oogenesis lose their centrosomes, although the mechanism of when and how remains elusive
predictions that molecular genetic approaches would answer definitively inheritance questions, following on the discovery of DNA in mitochondria (Nass and Nass, 1963; Margulis, 1970), failed.
[centrosomes and centrioles] assembly is tightly regulated and orchestrated
the question as to whether centrosomes and centrioles are inherited, strictly speaking, may need to be examined more stringently.
Centriole disassembly, studied here in oocytes during the last two meiotic divisions, remains challenging
The precise mechanism of CETN2 doublet separation is not currently known.
Investigations on the precise molecules essential for centriole persistence and PCM functionality in the doublets and their fates during oocyte growth and maturation to metaphase-II arrest await future studies.
Centriole destruction may be prerequisite for terminal differentiation, and the retention of centrioles is associated with proliferation, regeneration, pluripotency, perhaps even totipotency.
Perhaps the last phase of oogenesis (i.e., oocyte maturation) is another example of terminal differentiation, including with the elimination of centrioles and centrosomes. Interestingly, while it appears necessary to undergo two mitotic cycles to generate centrioles, perhaps during both spermatogenesis and oogenesis, the last two meiotic cycles also are prerequisite for centriole destruction.
Common Design 