The Spindle: Integrating Architecture and Mechanics across Scales

To perform its function, the spindle must be dynamic and flexible and yet able to generate force and maintain its integrity.

The robust function of the spindle emerges from the feedback between its architecture, dynamics, and mechanics across scales.

While we have a nearly complete list of spindle components, how their molecular-scale mechanics give rise to cellular-scale spindle architecture, mechanics, and function is not yet clear.