Yukiko Yamashita

 how germline stem cells orient their asymmetric cell divisions

The asymmetric division of stem cells gives rise to two daughter cells with different fates: one that retains stem cell identity and another that is destined to follow a particular developmental path. To guide the differential distribution of cell components, asymmetric division relies on the specific orientation of the dividing cell’s microtubule-based spindle apparatus. How this event occurs, and how it impacts stem cell behavior, are questions that fascinate