Growth Cone Tctp Is Dynamically Regulated by Guidance Cues

Growth Cone Tctp Is Dynamically Regulated by Guidance Cues

Tctp cellular levels are regulated in response to intra- and extracellular inputs, including growth signals and certain cytokines (Böhm et al., 1989; Nielsen et al., 1998; Teshima et al., 1998; Bommer et al., 2015), though the biological significance of this adaptive response remains largely unknown.

considering that the addition/removal of ubiquitin tags affects not only protein degradation by the proteasome and the lysosome, but also shapes protein function and localization, further investigation is needed to pinpoint the nature of growth cone Tctp regulation by Ephrin-A1.

pseudogenes can act as competing RNAs (ceRNAs)—i.e., microRNA sponges—and thus it is conceivable that tctp and/or its pseudogenes have an important influence as post-transcriptional regulators of gene expression in axons (Tay et al., 2014).

growth cone Tctp expression is dynamically regulated by guidance cues during axon guidance processes. While local protein synthesis contributes to this adaptive response, new Tctp protein production in axons appears to be dispensable for the normal progression of RGC axons through the optic tract.

RGC origin dictates distinct growth cone mTOR activation profiles in response to Ephrin-A1, a preliminary finding with potential implications to the understanding of visual topographic map formation.