Hematopoietic stem cells (HSCs) are rare cells that are maintained throughout life (self-renewing). They produce hematopoietic progenitor cells that differentiate into every type of mature blood cell within a well-defined hierarchy.
CD34 is routinely used to identify and isolate human hematopoietic stem/progenitor cells (HSPCs) for use clinically in bone marrow transplantation, but its function on these cells remains elusive.
a detailed explanation of how CD34 contributes to CD34pos HSPC engraftment into the BM remains unknown.
CD34 increases trafficking and migration of hematopoietic cells11,19; however, the precise mechanism is still not fully understood.
Common Design 