Mechanisms of learning and memory require a fine-tuned interplay between ion channels on hippocampal neurons.
the dendritic localization of HCN1 channels, a critical determinant of their function, is influenced by estrogen (E2), thus bringing attention to the modulatory roles of sex hormones on hippocampal information processing, which are yet poorly understood.
the subcellular distribution of HCN1 channels in CA1 is influenced by estradiol but does not require Reelin, as previously proposed (Kupferman et al., 2014).
Common Design 