Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration
It is extremely intriguing scientifically and critical clinically to identify these permissive signals of axon regeneration and elucidate the mechanisms by which they are cross regulated with the necessary mTORC1 signals. The increased understanding of the complicated cross-regulation and feedback-control mechanisms involved in PTNE-PI3K-AKT-mTORC1/2 will certainly inspire more studies on these critical growth control mechanisms, which will eventually lead to safe and effective therapeutic strategies for CNS injury, and to isolate them from targets that mediate deleterious effects.
Common Design 