Revisiting Netrin-1: One Who Guides (Axons)
Proper patterning of the nervous system requires that developing axons find appropriate postsynaptic partners
The macroscopic structures of axon projections are highly stereotyped across members of the same species, indicating precise mechanisms guide their formation.
The developing axon exhibits directionally biased growth toward or away from external guidance cues.
Development of an animal nervous system, […], requires that each neuron connect to proper target cells.
Further studies are needed to assess the extent of proteoglycan regulation of netrin-1 signaling pathways, and the mechanisms by which glypican and heparin sulfates influence chemotactic and haptotactic axon guidance.
Common Design 