EGFR signaling coordinates patterning with cell survival during Drosophilaepidermal development
in normal development, exposure to EGFR signalling dictates cell survival and is possibly involved in maintaining cell number and therefore compartment size.
tight regulation of cell death, as much as proliferation, enables the establishment of normal body and organ size during development.
apoptosis is triggered at embryonic stage 11, long after ftz should have fulfilled its function in segmentation and after the cessation of proliferation. It would be really interesting to know how this time-dependent sensitisation to low EGFR signalling is orchestrated – are there any contender mechanisms?
Common Design 